Sulfamethoxazole And Trimethoprim Oral Route Proper Use

Bacterial infections sometimes require pharmaceutical treatment, such as antibiotic medications. One common medication prescribed by doctors is trimethoprim-sulfamethoxazole (sometimes called co-trimoxazole or TMP/SMX), the generic form of Bactrim. Trimethoprim/sulfamethoxazole is an American pregnancy category D medication. Use during early pregnancy has been related to congenital malformations and maternal folic acid deficiency; this may cause neural tube defects (spina bifida), urinary tract defects, oral clefts, and clubbed feet. Use during late pregnancy has been related to preterm labor.

  1. BACTRIM is contraindicated in pediatric patients less than 2 months of age.
  2. Trimethoprim has a half-life of 8 to 10 hours, is minimally metabolized in the liver, and is primarily excreted in the urine, essentially unchanged.
  3. Use during late pregnancy has been related to preterm labor.

Use of the drug in children younger than two months of age is not recommended. Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed. Tell your doctor if you use other medicines or have other medical conditions or allergies. Lastly, trimethoprim-sulfamethoxazole can affect certain medical tests. If you need lab work done at the doctor or dentist, tell the provider that you’re taking this antibiotic. Trimethoprim-sulfamethoxazole works by decreasing the bacteria infecting a person’s body.

Bactrim for shigellosis

Alternatively, other epidemiologic studies did not detect statistically significant associations between sulfamethoxazole and trimethoprim exposure and specific malformations. Because sulfamethoxazole and trimethoprim may interfere with folic acid metabolism, BACTRIM should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus. Trimethoprim alone was negative in in vitro reverse mutation bacterial assays and in in vitro chromosomal aberration assays with Chinese Hamster ovary or lung cells with or without S9 activation. In in vitro Comet, micronucleus and chromosomal damage assays using cultured human lymphocytes, trimethoprim was positive.

More about Bactrim (sulfamethoxazole / trimethoprim)

If a significant blood dyscrasia or jaundice occurs, specific therapy should be instituted for these complications. Peritoneal dialysis is not effective and hemodialysis is only moderately effective in eliminating sulfamethoxazole and trimethoprim. Drug interactions may change how your medications work or increase your risk for serious side effects. This document does not contain all possible drug interactions. Keep a list of all the products you use (including prescription/nonprescription drugs and herbal products) and share it with your doctor and pharmacist.

Follow your doctor’s instructions, including how much to take and when, when prescribed trimethoprim-sulfamethoxazole. It’s important, too, to finish your course of treatment even if you begin to feel better. Your doctor will work with you to determine the appropriate dosage of trimethoprim-sulfamethoxazole based on your infection, its severity, and your general health. Sulfamethoxazole and trimethoprim combination is best taken with a full glass (8 ounces) of water. Several additional glasses of water should be taken every day, unless otherwise directed by your doctor. Drinking extra water will help to prevent some unwanted effects (eg, crystals in the urine).

If you stop taking this medicine too soon, your symptoms may return. The incidence of congenital abnormalities was 4.5% (3 of 66) in those who received placebo and 3.3% (4 4 ways to stop alcohol cravings of 120) in those receiving sulfamethoxazole and trimethoprim. There were no abnormalities in the 10 children whose mothers received the drug during the first trimester.

Warnings for Bactrim

Prepare an injection only when you are ready to give it. Call your pharmacist if the medicine looks cloudy, has changed colors, or has particles in it. Sulfamethoxazole and trimethoprim could make you sunburn more easily. Wear protective clothing and use sunscreen (SPF 30 or higher) when you are outdoors. This medicine should not be given to a child younger than 2 months old. This medication may interfere with certain lab tests, possibly causing false test results.

Bactrim for urinary tract infections (UTI)

Use of BACTRIM at high doses and/or for extended periods of time may cause bone marrow depression manifested as thrombocytopenia, leukopenia and/or megaloblastic anemia. If signs of bone marrow depression occur, the patient should be given leucovorin 5 to 15 mg daily until normal hematopoiesis is restored. During treatment, ensure adequate fluid intake and urinary output to prevent crystalluria.Patients who are “slow acetylators” may be more prone to idiosyncratic reactions to sulfonamides. Avoid coadministration of BACTRIM and leucovorin during treatment of P. jirovecii pneumonia (see WARNINGS).

On the other days of the week, the child will not take any doses of Bactrim. For example, if your child weighs 32 kg (about 70 lb), their doctor may prescribe two tablets of Bactrim (400 mg/80 mg) taken every 6 hours for 14–21 days. Alternatively, their doctor may prescribe one tablet of Bactrim DS (800 mg/160 mg) taken every 6 hours for 14–21 days.

Bactrim will not treat a viral infection (flu or a common cold). Check your symptoms, explore conditions and treatments, and if needed, text with a healthcare provider in detox basics minutes. To reduce the risk of unwanted side effects, drink a glass of water when you take trimethoprim-sulfamethoxazole and continue to drink water throughout the day.

High dosage of trimethoprim, as used in patients with P. jirovecii pneumonia, induces a progressive but reversible increase of serum potassium concentrations in a substantial number of patients. To date, there are limited data on the safety of repeated use of BACTRIM in pediatric patients under two years of age. BACTRIM is not indicated for prophylactic or prolonged administration in otitis media at any age.

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